# 35Pharma to be Acquired by GSK to Accelerate Development of HS235, a Potential Best-in-Class Investigational Medicine for Pulmonary Hypertension (PH)
**Date:** 2026-02-25 02:00:00
**Company:** GSK plc
**Ticker:** GSK
**Source URL:** https://www.globenewswire.com/news-release/2026/02/25/3244267/0/en/35Pharma-to-be-Acquired-by-GSK-to-Accelerate-Development-of-HS235-a-Potential-Best-in-Class-Investigational-Medicine-for-Pulmonary-Hypertension-PH.html
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# 35Pharma to be Acquired by GSK to Accelerate Development of HS235, a Potential Best-in-Class Investigational Medicine for Pulmonary Hypertension (PH)
**Date:** 2026-02-25 02:00:00
**Company:** GSK plc
**Ticker:** GSK
**Source URL:** https://www.globenewswire.com/news-release/2026/02/25/3244267/0/en/35Pharma-to-be-Acquired-by-GSK-to-Accelerate-Development-of-HS235-a-Potential-Best-in-Class-Investigational-Medicine-for-Pulmonary-Hypertension-PH.html
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# 35Pharma to be Acquired by GSK to Accelerate Development of HS235, a Potential Best-in-Class Investigational Medicine for Pulmonary Hypertension (PH)
February 25, 2026 02:00 ET\| Source:
[35Pharma](https://www.globenewswire.com/en/search/organization/35Pharma)Follow35Pharma
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- Acquisition includes HS235, a potentially best-in-class activin signalling inhibitor in clinical development for treatment of cardiopulmonary diseases
- HS235 offers potential to treat pulmonary hypertension (PH) patients while reducing the risk of bleeding and providing unique metabolic benefits compared to existing therapies
MONTREAL, Feb. 25, 2026 (GLOBE NEWSWIRE) -- 35Pharma, a Canada-based, private, clinical-stage biopharmaceutical company specialised in the development of novel protein-based therapeutics today announced it has entered into an agreement with GSK plc (GSK), under which GSK will acquire all of the outstanding equity interests in 35Pharma. The acquisition includes HS235, a potential best-in-class investigational medicine that has completed phase I healthy volunteer clinical trials with studies to start imminently in pulmonary arterial hypertension (PAH) and pulmonary hypertension due to heart failure with preserved ejection fraction (PH-HFpEF).
PH is a progressive, life-shortening disease marked by high blood pressure in the lungs. Early symptoms are breathlessness, fatigue and chest pain leading to heart failure as the disease progresses. It affects approximately 82 million people worldwide across multiple disease forms, yet treatment options remain limited and the five‑year survival rate is only around 50%.1,2 By 2032, the global market for PH therapies is forecast to reach $18 billion, with activin signalling inhibitors expected to account for 50% of this.3
HS235 targets the activin receptor signalling pathway, a clinically validated therapeutic target in PAH. HS235 is designed with enhanced selectivity, reducing binding to BMP9 and BMP10 - ligands associated with adverse events such as bleeding and telangiectasia (broken blood vessels). By potentially lowering the risk of bleeding, HS235 may address a key limitation in current PH treatment, particularly as a significant proportion of patients require concomitant anticoagulant or antiplatelet therapy.
The underlying mechanism of HS235 offers the potential for broad metabolic benefits, including fat-selective weight loss, preservation of lean mass, and improved insulin sensitivity, supported by beneficial changes in inflammation and adipokines (fat hormones) observed in early clinical studies. These attributes may offer additional clinical and commercial value given the high prevalence of obesity and insulin resistance in the PH population.
**Ilia Tikhomirov, CEO, 35Pharma** **,** said: “In recent years, we witnessed a revolution in our understanding of pulmonary hypertension and how this life-threatening disease could be reversed. We are pleased to be combining our efforts with GSK, a leader in respiratory and inflammatory drivers of disease, who shares our vision of HS235’s potential to transform the treatment of this debilitating condition.”
**Tony Wood, Chief Scientific Officer, GSK** **,** said: “Pulmonary hypertension affects millions of people worldwide, yet patients are underserved. We’re delighted to add HS235 to our pipeline, a potential best-in-class medicine with a differentiated profile to reduce risk of bleeding and provide potential metabolic benefits clinically relevant to PH patients. HS235’s potential protective effects on vascular function, alongside potential benefits on fat-derived markers of metabolism and inflammation, also offer new development opportunities within our RI&I portfolio to achieve broader coverage across the metabolic, inflammatory, vascular and fibrotic drivers of multiple chronic diseases that affect the lung, liver and kidney.”
**Maureen O’Connor, CSO, 35Pharma** **,** said: “HS235 is a unique and potentially best-in-class agent that we designed guided by the most recent advances in the field. This acquisition reflects the exceptional work of our team in building the scientific and clinical capabilities to discover and advance HS235 through clinical proof of biology in healthy volunteers. We are proud to collaborate with GSK to accelerate development of this medicine which could help millions of patients affected by pulmonary hypertension, a life-threatening group of diseases.”
**Financial considerations**
Under the terms of the agreement, GSK will acquire 100% of the equity of 35Pharma Inc. for $950 million, payable in cash at closing.
This transaction is subject to customary conditions, including applicable regulatory agency clearances under the Hart-Scott-Rodino Act in the US and the Competition Act in Canada, along with a filing under the Investment Canada Act.
**Advisors**
Centerview Partners LLC acted as financial advisor to 35Pharma and Cooley LLP served as US legal counsel and Stikeman Elliott LLP as Canadian legal counsel. J.P. Morgan Securities LLC also provided financial advice to 35Pharma.
**About pulmonary hypertension**
There are different types of PH such as Pulmonary Arterial Hypertension (PAH) and PH due to Heart Failure with preserved Ejection fraction (PH-HFpEF). PH is treated in specialised academic centres by pulmonologists and cardiologists, where PH programs sit within larger lung, respiratory and critical care centres. Around 82 million people worldwide are affected by PH and in the US, the addressable patient population for PAH and PH-HFpEF is approximately 100,000 people.1,4,5
**About 35Pharma Inc.**
35Pharma is a clinical-stage biopharmaceutical company developing novel TGF-beta superfamily therapeutics. 35Pharma’s lead candidate, HS235, is being developed for the treatment of cardiopulmonary diseases with clinical trials initiated in Pulmonary Arterial Hypertension and PH due to Heart Failure with preserved Ejection fraction. For more information visit [www.35pharma.com](https://www.globenewswire.com/Tracker?data=l8OgRjeF-QFiIWxwGwLQmRcztgkAvJPuCSH9PzronU7NUPze11y_6erUJHuOCUO2_Ob19dadqHphfac5ObwvEL3yzPDoXdOfmrg58luehAw= "www.35pharma.com").
**About GSK**
GSK is a global biopharma company with a purpose to unite science, technology, and talent to get ahead of disease together. Find out more at [www.gsk.com](https://www.globenewswire.com/Tracker?data=qCmghhhKZ0VeIaCFRVJX5-A1VHCYzmXF5iQwZdDViU2pfJ2x9GU1EhmOp6Xw70EJiWEXlnyyXgUEAaMlWIn6Fg== "www.gsk.com").
**Contact**
Julia Schoelermann, VP Corporate Development
[ir@35pharma.com](https://www.globenewswire.com/Tracker?data=zqkk59hGXzEb37MW3pmKtZ0uPeJfjAMtQVGMTjecCdazCEXih9FGXE4hYPblneGTjdna-7a4VzSlA4_Fd--O-r0kaMeD2KoTIhJSEUxj6y8= "ir@35pharma.com")
**References**
1\. Humbert, M. et al. (2022) 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension, European Heart Journal, 43(38), pp. 3618–3731. doi:10.1093/eurheartj/ehac237.
2\. Caravita S, Faini A, D’Araujo SC, et al. Clinical phenotypes and outcomes of pulmonary hypertension due to left heart disease: Role of the pre-capillary component. PLOS ONE. 2018;13(6):e0199164. doi:10.1371/journal.pone.0199164.
3\. Evaluate Pharma consensus estimate; accessed Feb 2026.
4\. Leary, Peter J et al. The Lancet Respiratory Medicine, Volume 13, Issue 1, 69-79.
5\. GSK Internal data.
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